Experiencing hot flashes, extreme fatigue, insomnia, mood swings, or low libido? You're not alone. These are common pre menopause symptoms that many women face during the transition to menopause—also known as perimenopause.
If you're in your late 30s, 40s, or early 50s, understanding the root cause of these changes is key. Before exploring treatment options, it's essential to rule out other conditions like thyroid dysfunction, stress, or anxiety—which can mimic premature menopause symptoms.
Today, we're focusing on one treatment that's gained attention in recent years: hormone pellets.
Hormone pellets are tiny implants—about the size of a grain of rice—inserted just under the skin, usually in the upper buttocks. This quick, in-office procedure takes only 10–15 minutes and is minimally painful.
These pellets deliver bioidentical hormones like estradiol and/or testosterone, slowly releasing them over 3 to 6 months to provide steady symptom relief for perimenopause and menopause.
Bioidentical hormones are chemically identical to those naturally produced by your body, including estradiol, testosterone, and progesterone.
Compounded bioidentical hormones are custom-made formulations often prepared by specialized pharmacies. These may lack formal approval or standardization.
✅ Hormone pellets typically use FDA-approved bioidentical hormones, making them a more regulated option than many compounded therapies.
Clinical studies and patient reports show significant benefits for women experiencing:
Pia Mancini, co-founder and CEO of Give Zero, shares her story:
"When I was dealing with crushing fatigue and constant migraines, a doctor suggested testing my testosterone. My levels were extremely low, and he recommended a pellet. But I was hesitant—what if it didn't agree with me and I couldn't take it out?"
"I asked around and found a gynecologist who offered a testosterone cream instead. That felt safer. Even at a quarter of the recommended dose, I felt amazing—more energy, like myself again. But when I used the full dose? Insomnia and heart palpitations hit hard."
"My advice: try a very low dose or cream first. You can always work up to a pellet if it's right for you."
Hormone therapy with estradiol is FDA-approved for:
⚠️ Important: Testosterone pellets are not FDA-approved for women in the U.S. but may be used in other countries under careful medical supervision.
Hormone pellets are generally safe when prescribed by a menopause specialist. But possible side effects include:
Some women also experience overstimulation from hormones, leading to insomnia, heart palpitations, or heightened anxiety.
You should avoid hormone pellet therapy if you have:
‼️ Red Flag: If a provider offers you hormone pellets without first doing a full hormone panel and personalized evaluation, seek a second opinion.
Whether you're 35 and starting to notice early perimenopause symptoms, or you're in full menopause, here's what you should remember:
Every woman's menopause journey is different. What works for one may not work for another—and that's okay. The goal is to help you feel like yourself again and navigate this transition with confidence, support, and clarity.