You've got questions? We have answers. Start here for a quick glance at perimenopause and menopause basics. For a deep dive or specifics about your symptoms, go ahead and login to chat to our AI Health Companion, Nova.
It's the day you've gone 12 months without a period. Everything before (since the onset of symptoms) is called perimenopause, everything after is post-menopause.
It involves both the ovaries and the brain, affecting mood, cognitive function, sleep, metabolism, and the musculoskeletal system.
Hormones fluctuate wildly during this stage, unlike the more stable patterns of pre- or post-menopause. In perimenopause there's a lot of volatility — your estrogen may be at its peak the day you get tested and then crash the following week.
Around 85% of women feel symptoms during this transition, and each woman's experience is unique.
Periods may become lighter or much heavier, closer together or more apart. Many women don't recognize this as perimenopause.
Estrogen is a powerful antinflamatory and we have estrogen receptors all over our bodies. When estrogen lowers different areas can get inflamation. Symptoms range widely and depend on individual biology.
We have estrogen receptors in muscles, bones, metabolism, and the brain. When estrogen fluctuates, multiple systems are impacted.
Women are twice as likely as men to develop Alzheimer's. Women experience 4x more migraines. Women are 3x more likely to develop autoimmune brain disorders like multiple sclerosis. Menopause is as much a neurological shift as a reproductive one. Women's brains have a unique plasticity in that they rewire in response to hormonal cues. This is what allows us to bond with newborns. This ability also explains why our brains change during this transition.
After the rewiring that happens during this transition where our brains need to adapt to operating without estrogen, the brain functions that are affected come back. Of course our brains are ageing but the transition ends and the capabilities return. In fact women during and after the transition perform better than men the same age in memory and other cognitive tasks.
Postmenopausal women often report higher levels of happiness and empathy compared to premenopausal women.
Melatonin can drop by 50% around age 50. About 69% of women past reproductive age report sleep problems. Those 3 a.m. wake-ups are hormone-driven—you are not alone.
Estrogen regulates metabolism. As it fluctuates, the body may shift how it stores and redistributes fat.
We combine your data (symptoms, labs, wearables) with clinically reviewed information to create a personalized action plan and ongoing coaching. Our AI companion Nova is available 24/7 to answer questions, track your progress, and help you prepare for doctor appointments.
Give Zero provides education and support to help you make informed decisions with your clinician. We don't replace your doctor—we help you become a more informed partner in your care.
Yes. Your health data is completely private and secure. We use industry-standard encryption and never share your personal information without your explicit consent.
Give Zero is completely personalized to your unique experience. We don't offer one-size-fits-all advice. Instead, we use your symptoms, lab results, and wearable data to create a plan that's tailored to you—and it evolves as you do.
Start by taking the Compass Check-in. It takes about 10 minutes and helps us understand your symptoms, health history, and goals. From there, you'll get a personalized action plan and access to Nova, your AI health companion.
No. While lab results can enhance your personalized plan, you can start with just your symptoms. Give Zero will help you understand which tests might be helpful to discuss with your clinician.
That's exactly why Give Zero exists. Many women experience symptoms for years before getting a diagnosis. Our Compass Check-in can help you identify patterns and give you the language to discuss your experience with your doctor.
Yes! Give Zero helps you track how treatments are working, identify breakthrough symptoms, and optimize your care over time. Many women use Give Zero to prepare for follow-up appointments and adjust their treatment plans.